Can You Overdose Prazipro

Last Updated on December 23, 2021 by cmoarz

A common question people ask before using Prazipro is can you overdose prazipro?

It is understandable that people would worry about overdosing prazipro as it is a medication that most people haven’t heard of before. Adding anything new to your fish tank can be a scary experience, So let’s put your mind at ease.

Can You Overdose Prazipro

Can you overdose on prazipro? Yes, you can, But the doses required are fairly high. In some circumstances, people have had to use up to 3x the normal dose to deal with certain species of flukes.

3x is a very high dose and I would never recommend anyone who isn’t an experienced fish keeper to try and treat a whole tank with such a high dosage.

What are the symptoms of a Prazipro overdose?

  • Fish breathing heavily at the surface of the tank
  • Darting back and forth
  • Flashing
  • Loss of appetite
  • Death
  • Low oxygen (Prazipro saps oxygen out of the water, so always over oxygenate when treating with it)

Symptoms that might happen even if you don’t overdose which are normal:

  • Loss of appetite
  • Slight agitation (which is often attributed to the parasites infecting the fish themselves)

Will Prazipro Kill My Fish?

In general, Prazipro is a powerful medication but it’s pretty calm even on the most sensitive fish.

Prazipro should not kill your fish if you follow the proper dosage instructions. If your fish die during the use of prazipro, it was almost certainly because of the parasites you were trying to treat to begin with.

If you follow the dosage instructions, Prazipro is almost completely harmless to your fish. I have used it on several occasions without any problems whatsoever. It isn’t until you double or triple the dose that there is any risk at all.

It’s important to remember to add excessive oxygenation when treating with Prazipro though. It uses up a lot of oxygen out of the water column.

What Does Prazipro Kill?

Prazipro is an effective medication for killing various types of worms. It also has secondary ingredients that work for other small protozoa parasites.

These worms include flukes, tapeworms, flatworms, and turbellarians.

Is Prazipro Safe for All Fish?

Super sensitive critters like snails and shrimp are fine with prazipro, as are most other fish that I know of. It’s always important to research your specific fish to see if there’s anything you should be worried about, but prazipro is generally considered safe for any fish.

Certain kinds of fish are just more sensitive to medications than others. If your fish start exhibiting symptoms that they are being affected by the medication, stop treatment immediately and switch to something else.

For the most part though, Prazipro only targets flatworms. So if you have a pet flatworm, you may want to avoid it!

How Do I Treat My Aquarium With Prazipro?

Instructions taken directly from Hikari. You can find them here

Hikari Directions For Use

For treatment of praziquantel-susceptible disease conditions in pond, freshwater and marine aquariums and ornamental pond fishes.

Start each treament or retreatment with as large a water change as practical (at least 30%) or start with new water. Any water used should first be conditioned with Ultimate® or a combination of Liquid Buffered ClorAm-X® and Stress-X™ to remove ammonia, chlorine and chloramines. Do not stop filtration, but remove activated carbon and stop foam-fractionation (protein skimming) and UV sterilization-failure to do so will render product ineffective. SHAKE VIGOROUSLY before use. Measure Liquid PraziPro® at the rate of one (1) teaspoon (~5mL) per 20 (76L) gallons of water to be treated (one [1] fl. oz. [29.5 mL] per 120 gallons [454L]). Care should be taken to treat the exact amount of water in the system. This means deductions for substrate, rock or coral and any other internal equipment is necessary. You can calculate the amount of water in your aquarium by taking a measurement of the length x width x depth of the area with water and dividing by 231 for approximate volume. This produces a concentration of 2.5 mg/L. Distribute the proper amount around the edge of the pond or aquarium or directly in to the filter box to achieve the best overall distribution. A single treatment lasting 5-7 days may be sufficient. Retreat as necessary, but no more than once every 3 days. May be used as a preventative, at the standard dosage, when disease is likely. Do not use with any other drugs or disease treatments. May cause noticeable temporary foaming. It’s important to note that most parasites in the class that PraziPro® would be used for have up to a 28 day life cycle. This means for major issues, up to four (4), uninterrupted treatments may be required to resolve the issue. Over dosing will not speed impact.

DO NOT OVERDOSE – this means you should calculate the actual amount of water in your tank by multiplying the length x width x height and dividing by 238 to get the true gallons. Please also deduct the amount of space consumed by substrate (gravel, sand, etc.) rock, decorations or other things which are displacing water.

NOTE: We do not recommend using any sulfur or sulfinite-based water conditioners with this product. If your normal water conditioner does not list the ingredients please verify with the maker that it does not contain these ingredients. If you notice any rotten egg smell to the product, it likely does have these ingredients and should be avoided as it could cause the product to be less effective and the dissolved oxygen levels to be negatively impacted.

Use Liquid PraziPro® any time unwanted parasites are noticed or introduction is probable.

Compatibilities: There are no known compatibility issues with the use of Liquid PraziPro® except for use in marine (saltwater) systems where flatworms of the Polycladida order are being cultured and when used where feather duster worms (sabellidae) or delicate worm-type relatives are kept. For heavily stocked aquariums or marine aquariums with lots of coral, added aeration is suggested.

Because we care: PraziPro® has been developed to offer assistance to aquarium or pond keepers who are encountering problems with unwanted worms or parasites and for ease of use by the user.


Owner of and also owner of actual Aquarium Gravel believe it or not! ;). Setting up beautiful aquarium sceneries and habitats since I was very young. Enjoy!